11/6/2023 0 Comments Rhinoceros drawing for kids![]() The goal of sentinel lymph node biopsy (SLNB), in general, is to detect putative subclinical micrometastases in the regional lymph nodes which otherwise escape detection by ultrasound imaging and clinical examination. 1, 10, 11, 14 These data, however, stem from an era before the availability of targeted therapies and checkpoint inhibition, which have become regular components in the management of a multitude of tumors, including metastatic cutaneous melanoma, and hopes are high that patients with CM will be able to benefit from these as well. ![]() Reported 10-year mortality rates range somewhere from 13%–32%. However, these rates tend to vary strongly between populations with one study reporting up to 41% lymph node metastasis within 6 years. 10 Akin to the phenotypically related cutaneous melanoma, initial metastasis predominantly, though not exclusively, occurs to the regional lymph nodes (as opposed to uveal melanomas which typically initially metastasize to the liver) and can be observed in 16%, 26%, and 32% of patients within 5, 10, and 15 years, respectively. Melanoma of the temporal bulbar conjunctiva with a prominent feeder vessel in the left eye of a patient.ĭespite all these efforts, CM is characterized by high recurrence rates of approximately 26%, 51%, and 65% within 5, 10, and 15 years after primary therapy, respectively. However, there is not enough evidence to support SLNB as a mandatory part of CM management. ![]() Adverse events reported were non-severe and transient.Ĭonclusion: Patients can potentially benefit from SLNB and the procedure can be offered to eligible patients. Reported 5-year survival rate following CM management including SLNB, is up to 79%, but there are no comparative cohort studies proving the assumed benefit. Failure to identify SLNB has been attributed to the surgical learning curve and recurrent tumors with scar tissue impeding spread of the tracer material. False negative SLNB findings are rare (<10%). Although indication criteria for SLNB vary slightly, positive findings can be expected in 11%–13% of CM cases, including small tumors. Results: Data on SLNB in the management of CM are scarce and only two relatively large cohorts have been reported. Methods: This article provides a review of the literature from PUBMED. Purpose: To evaluate the role of sentinel lymph node biopsy (SLNB) in conjunctival melanoma (CM).
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |